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The 5-MeO group includes the following 5-MeO-AMT, 5-MeO-DALT, 5-MeO-DET, 5-MeO-DMT, 5-MeO-DIPT, 5-MeO-MIPT, and others. The most commonly used 5-MeO chemicals are 5-MeO-AMT, 5-MeO-DALT and 5-MeO-DMT.
5-MeO-DMT is a naturally occurring psychedelic present in numerous plants and in the venom of the Bufo alvarius toad. It is found in some traditional S. American shamanic snuffs used in rituals and sometimes in ayahuasca brews.
5-MeO DALT (or N, N-diallylmethoxytryptamine), is a synthetic, psychedelic drug belonging to the ‘tryptamine’ class which includes drugs such as DMT. It was first synthesised by Shulgin in 2004 as an analogue of DMT and produces similar stimulant and spiritual (entheogenic) effects.
There have been no reported deaths associated with taking 5-MeO DALT by itself. In July 2010, a man in his 20s was hit and killed by a heavy goods vehicle on a UK motorway after having taken 350mg of 5-Meo DALT (more than 10 times a typical dose) and drinking alcohol earlier in the evening.
NOTE: despite the similarities in name and some of the effects, 5-MeO-DMT should not be confused with DMT.
5-MeO-DMT (6) is a tryptamine natural product most commonly identified as the primary psychoactive component of the parotid gland secretions of Incilius alvarius, the Sonoran Desert toad The alkaloid is also known to be present in low concentrations in a variety of plants, shrubs, and seeds. Human consumption of this material for its psychoactive properties has been reported in the scientific literature for at least 100 years. Although it has been historically suggested that 5-MeO-DMT may have been used by indigenous cultures, there is no known documentation to support this assertion. Due to the recent discovery of high concentrations of 5-MeO-DMT in I. alvarius secretions, there has been a reported increase in its recreational and spiritual use. Recent evidence has indicated the presence of 5-MeO-DMT existing in concentrations between 20 and 30% of total dry weight or approximately 200–300 mg of 5-MeO-DMT per dried gram of toad secretion, concentrations much higher when compared to plant-derived sources of 5-MeO-DMT.
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When used as a drug in its purified form, 5-MeO-DMT is smoked, insufflated, or injected and is active at a dose of as little as 2 mg. 5-MeO-DMT is also active orally, when taken with an monoamine oxidase inhibitor, but according to numerous reports, the combination with MAOI is extremely unpleasant and has a strong body-load. According to the researcher Jonathan Ott, 5-MeO-DMT is active orally with doses over 30 mg without aid of a MAOI.
The onset of effects occurs in seconds after smoking/injecting, or minutes after insufflating, and the experience is sometimes described as similar to a near-death experience. Peak effects last for approximately 5-10 minutes, when smoked. When insufflated, the peak effects are considerably less intense, but last for 15-25 minutes on average.
Although similar in many respects to its close relatives DMT and bufotenin (5-OH-DMT), the effects are typically not as visual. Some users report experiencing no visual effects from it even at very high doses.[2]
Some report the effects to be unpleasant causing nausea and the feeling of being “sat on by an elephant”.[3]
Erowid lists the following effects for smoked 5-MeO-DMT:[2]
Positive
- immersive experiences
- powerful “rushing” sensation
- radical perspective shifting
- profound life-changing spiritual experiences
- some people experience erotic / sensual enhancement
- occasional euphoria
- internal visions (actual visual effects not as common)
- journey into mind
Neutral
- short duration
- change in perception of time
- experience of “the void“
- lack of memory of experience
- muscle jerking, twitching, abnormal vocalizations
- unconsciousness / nonresponsiveness lasting 5-20 minutes
- dissociation
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Pharmacology
Surveys and naturalistic studies of 5-MeO-DMT users reported a safe profile, and a strong potential for psychotherapeutic benefits. It is a short lasting psychedelic (30-90 minutes), which may be clinically advantageous in certain circumstances over longer lasting compounds such as psilocybin (4-6h) and LSD (8-10h).
Therapeutic benefits
5-MeO-DMT appears to be associated with sustained enhancement of satisfaction with life and mindfulness-related capacities, as well as improvements in self-reported depression and anxiety.
Need for more research
Despite all the advantages stated above, 5-MeO-DMT remains scientifically neglected and underexplored, and no brain-imaging study or clinical trial has been carried out with this compound to date. Buy 5-MEO DMT Vape Carts UK ,order 5 meo dmt vape carts online England , where to buy Vapes carts online Scotland , Wales
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